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氨苯砜可以治疗红斑狼疮吗?

来源:华人健康网 | 发布时间:2010-07-26 08:52:10 | www.chinesejk.com

  而红斑狼疮患者中50%可出现皮肤红斑,类皮损,所以将其用于治疗以皮损为主的红斑狼疮时常能取得一定疗效,逐渐地,皮肤科的医生们将氨苯砜用于治疗盘状红斑狼疮,播散性盘状红斑狼疮,亚急性皮肤型红斑狼疮,红斑狼疮的皮肤血管炎等各种皮肤、粘膜损害患者的治疗,多能使皮损范围缩小,症状改善,但对于系统性红斑狼疮出现脏器损害者效果不好,经实验研究证明:氨苯砜除了有抗麻风杆菌作用外,还能抑制溶酶体酶的活性,并作用于免疫反应中的化学介质,因红斑狼疮是一种自身免疫病,其发病是由于体内产生了针对自身抗原的抗体,抗原抗体复合物易沉积在血管壁,吸引补体,释放化学介质,引起中性粒细胞化学趋向性,并释放溶酶体酶,从而造成血管病变,脏器损害,而氨苯砜正是作用于此环节中的化学介质,并抑制溶酶体酶减轻免疫反应,缓解临床症状,所以氨苯砜可用于治疗红斑狼疮。具体用法:成人每日50~150mg,皮损控制后逐渐减量,维持在每日25~100mg,注意服药期间定期查血常规。

(编辑:小米 )

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