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非胰岛素依赖型糖尿病

来源:华人健康网 | 发布时间:2011-03-11 14:09:33 | www.chinesejk.com
非胰岛素依赖型糖尿病(NIDDM)的高血糖是多种因素的综合性后果,其中以胰岛素受体或受体后缺陷与胰岛素抵抗为主要环节。①胰岛素受体或受体后缺陷,使肌肉、脂肪等组织摄取与利用葡萄糖减少,以致血糖增高。②由于胰岛素相对不足与拮抗胰岛素增多使肝糖元分解及糖元异生增多,以致肝糖输出增多。③由于胰岛B细胞缺陷以致胰岛素分泌不足而致高血糖。④持续或长期高血糖刺激胰岛B细胞分泌增多,但由于受体或受体后异常而呈胰岛素抵抗性,以致B细胞功能衰竭。

(编辑:阳阳 )

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