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一种新的1型糖尿病亚型

来源:华人健康网 | 发布时间:2011-12-06 01:01:55 | www.chinesejk.com
1型糖尿病分为2种亚型:自身免疫型(1A)和特发型(1B)。日本的一个IDDM研究组对56例1型糖尿病者按有无谷氨酸脱羧酶(GAD)抗体进行分组,36例GAD抗体阳性;9例抗体阴性并糖化血红蛋白(HbA1c)>11.5%;11例抗体阴性并HcA1c<8.5%。与前两组相比,第3组平均高血糖持续时间较短(4.0天),平均血糖水平较高(773mg/dl[43mmol/L]),但HbA1c水平较低,代谢紊乱较严重,伴有酮症酸中毒,血清胰腺酶较高,没有胰岛细胞和胰岛素抗体。研究者认为一些特发性1型糖尿病患者具有非免疫性和急进性的特点。它起病急,血清胰腺酶水平高却没有胰岛炎、急、慢性胰腺炎,也检测不到糖尿病相关抗体。


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